New pyrrole-based amino acids for the synthesis of peptidomimetic constrained scaffolds

被引：23

作者：

Alongi, M ^{[1
]}

Minetto, G ^{[1
]}

Taddei, M ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 41期

关键词：

Paal-Knorr reaction; cyclocondensation; microwaves; peptides;

D O I：

10.1016/j.tetlet.2005.07.155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new family of pyrrole-based amino acids have been prepared through the microwave assisted Paal-Knorr reaction of 1-4 ketoesters derived from the corresponding beta-ketoester with a functional homologation. The carboxylic group is located in position 3 of the pyrrole, whereas the amino group, protected with the Cbz moiety, is present on the side chain in positions I or 2. These compounds were used to prepare constrained oligopeptides. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7069 / 7072

页数：4

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