Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation

被引：20

作者：

Ortiz-Maldonado, Valentin ^{[1
,2
]}

Frigola, Gerard ^{[3
]}

Espanol-Rego, Marta ^{[4
]}

Balague, Olga ^{[2
,3
]}

Martinez-Cibrian, Nuria ^{[1
]}

Magnano, Laura ^{[1
,2
]}

Gine, Eva ^{[1
,2
,5
]}

Pascal, Mariona ^{[4
]}

Correa, Juan G. ^{[1
]}

Martinez-Roca, Alexandra ^{[1
]}

Cid, Joan ^{[2
,6
]}

Lozano, Miquel ^{[2
,6
,7
]}

Villamor, Neus ^{[2
,5
,8
]}

Benitez-Ribas, Daniel ^{[2
,4
]}

Esteve, Jordi ^{[1
,2
,9
]}

Lopez-Guillermo, Armando ^{[1
,2
,5
,7
]}

Campo, Elias ^{[2
,3
,5
,7
,8
]}

Urbano-Ispizua, Alvaro ^{[1
,2
,7
,9
]}

Juan, Manel ^{[2
,4
,7
]}

Delgado, Julio ^{[1
,2
,5
,7
]}

机构：

[1] Hosp Clin Barcelona, Dept Hematol, Barcelona, Spain

[2] Inst dInvest Biomed August Pi Sunyer IDIBAPS, Oncol & Hematol, Barcelona, Spain

[3] Hosp Clin Barcelona, Dept Pathol, Barcelona, Spain

[4] Hosp Clin Barcelona, Dept Immunol, Barcelona, Spain

[5] Ctr Invest Biomed Red Canc CIBERONIC, Barcelona, Spain

[6] Hosp Clin Barcelona, Dept Hemotherapy & Hemostasis, Apheresis & Cell Therapy Unit, Barcelona, Spain

[7] Univ Barcelona, Dept Med, Barcelona, Spain

[8] Hosp Clin Barcelona, Hematopathol Unit, Barcelona, Spain

[9] Inst Res Josep Carreras, Stem Cell Transplant & Cell Immunotherapy Grp, Barcelona, Spain

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

CLL; CART; CD19; DLBCL; Richter disease; CHIMERIC ANTIGEN RECEPTOR; RECOMMENDATIONS;

D O I：

10.3389/fonc.2022.828471

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter's transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade >= 3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high-risk CLL or RT.

引用

页数：7

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