Roles of transforming growth factor-α in mammary development and disease

被引：24
|
作者：
Booth, Brian W. [1 ]
Smith, Gilbert H. [1 ]
机构：
[1] NCI, NIH, Mammary Biol & Tumorigenesis Lab, Bethesda, MD 20892 USA
来源：
GROWTH FACTORS | 2007年 / 25卷 / 04期
关键词：
TGF alpha; mammary; development; cancer;
D O I：
10.1080/08977190701750698
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transforming growth factor-alpha (TGF alpha) is a member of the epidermal growth factor (EGF) family. Expression of TGFa is highly regulated in response to exogenous cellular signals including cytokines and other growth factors. The growth factor has been found to be indispensable for proper development of many tissues and organs. TGFa has also been implicated in numerous disease states including forms of breast cancer. This minireview summarizes the basic biology of TGFa and its actions during normal and pathogenic development of the mammary epithelium.
引用
收藏
页码：227 / 235
页数：9
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