Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

被引：39
|
作者：
Calo, Enrica [1 ]
de Barros, Joao M. S. [1 ]
Fernandez-Gutierrez, Mar [2 ,3 ]
San Roman, Julio [2 ,3 ]
Ballamy, Lucy [4 ]
Khutoryanskiy, Vitaliy V. [1 ]
机构：
[1] Univ Reading, Reading Sch Pharm, Reading RG6 6AD, Berks, England
[2] CSIC, Inst Polymer Sci & Technol, C Juan Cierva 3, Madrid 28006, Spain
[3] CIBER BBN, C Monforte Lemos 3-5, Madrid 28029, Spain
[4] ConvaTec UK Ltd, First Ave,Deeside Ind Pk, Uxbridge CH5 2NU, Flint, Wales
来源：
RSC ADVANCES | 2016年 / 6卷 / 60期
关键词：
DRUG-DELIVERY; DRESSINGS; SYSTEMS; IODINE;
D O I：
10.1039/c6ra08234c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus. The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).
引用
收藏
页码：55211 / 55219
页数：9
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