Control of immune pathology by regulatory T cells

被引：246
|
作者：
Mason, D
Powrie, F
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, MRC, Cellular Immunol Unit, Oxford OX1 3RE, England
[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England
来源：
CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0952-7915(98)80084-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is now compelling evidence that immune responses for both foreign and self antigens are downregulated by T cells that are specialised for this function; these are known as regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on the antigen specificity, generation and mode of action of T reg cells is also reviewed.
引用
收藏
页码：649 / 655
页数：7
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