Continued low-dose decitabine (DAC) is an active first-line treatment.: In all cytogenetic subgroups of older AML patients:: Results of the FR00331 multicenter phase II study

被引:9
|
作者
Luebbert, Michael [1 ]
Rueter, Bjorn [1 ]
Claus, Rainer
Schmid, Mathias [2 ]
Germing, Ulrich [3 ]
Eimeracher, Hartmut [4 ]
Ganser, Arnold [5 ]
Platzbecker, Uwe [6 ]
Galm, Oliver [7 ]
Brugger, Wolfram [8 ]
Heil, Gerhard [9 ]
Wijermans, Pierre W. [10 ]
Pfeifer, Dietmar [1 ]
Schmoor, Claudia [11 ]
Doehner, Hartmut [2 ]
机构
[1] Univ Hosp, Freiburg, Germany
[2] Univ Hosp, Ulm, Germany
[3] Univ Hosp, Dusseldorf, Germany
[4] Catholic Hosp, Hagen, Germany
[5] Univ Hosp, Hannover, Germany
[6] Univ Hosp, Dresden, Germany
[7] Univ Hosp, Aachen, Germany
[8] Hospital, Villigen Schwenningen, Germany
[9] Hospital, Ludenscheid, Germany
[10] Leyenburg Hosp, The Hague, Netherlands
[11] Univ Hosp, Ctr Clin Trials, Freiburg, Germany
关键词
D O I
10.1182/blood.V110.11.300.300
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
300
引用
收藏
页码:95A / 95A
页数:1
相关论文
共 50 条
  • [41] Cetuximab monotherapy and cetuximab plus capecitabine as first-line treatment in older patients with RAS- and BRAF wild-type metastatic colorectal cancer. Results of the multicenter phase II trial SAKK 41/10
    Kienle, Dirk L.
    Dietrich, Daniel
    Ribi, Karin
    Wicki, Andreas
    Quagliata, Luca
    Winterhalder, Ralph C.
    Koeberle, Dieter
    Horber, Daniel
    Bastian, Sara
    Kueng, Marc
    Saletti, Piercarlo
    Helbling, Daniel
    Baertschi, Daniela
    Lugli, Alessandro
    Bernhard, Juerg
    Andrieu, Christiane
    von Moos, Roger
    JOURNAL OF GERIATRIC ONCOLOGY, 2019, 10 (02) : 304 - 310
  • [42] DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy
    Grishina, Olga
    Schmoor, Claudia
    Doehner, Konstanze
    Hackanson, Bjoern
    Lubrich, Beate
    May, Annette M.
    Cieslik, Caroline
    Mueller, Michael J.
    Luebbert, Michael
    BMC CANCER, 2015, 15
  • [43] High-dose sequential chemotherapy (HDS) versus PEB chemotherapy as first-line treatment of patients with poor prognosis germ-cell tumors: mature results of an Italian randomized phase II study
    Necchi, A.
    Mariani, L.
    Di Nicola, M.
    Lo Vullo, S.
    Nicolai, N.
    Giannatempo, P.
    Raggi, D.
    Fare, E.
    Magni, M.
    Piva, L.
    Matteucci, P.
    Catanzaro, M.
    Biasoni, D.
    Torelli, T.
    Stagni, S.
    Bengala, C.
    Barone, C.
    Schiavetto, I.
    Siena, S.
    Carlo-Stella, C.
    Pizzocaro, G.
    Salvioni, R.
    Gianni, A. M.
    ANNALS OF ONCOLOGY, 2015, 26 (01) : 167 - 172
  • [44] Results of a multicenter phase II trial for older patients with c-Kit positive acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) using low-dose Ara-C (LDAC) and imatinib.
    Heidel, F
    Cortes, J
    Ruecker, F
    Kaufmann, M
    Aulitzky, W
    Letvak, L
    Kindler, T
    Huber, C
    Dohner, H
    Kantarjian, H
    Fischer, T
    BLOOD, 2005, 106 (11) : 527A - 527A
  • [45] Anti-PD-1 antibody (sintilimab) plus decitabine as first-line treatment for patients with higher-risk myelodysplastic syndrome (MDS): Preliminary results from a single-arm, open-label, phase II study.
    Wang, Jing
    Li, Siqi
    Jiang, Hao
    Chang, Ying-Jun
    Zhao, Xiao-Su
    Jia, Jin-Song
    Zhu, Xiao-Lu
    Gong, Li-Zhong
    Liu, Xiao-Hong
    Yu, Wen-Jing
    Huang, Xiao-Jun
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [46] Updated survival outcomes of the phase II study of low starting dose of afatinib as first-line treatment in patients with EGFR mutation-positive non-small cell lung cancer (KTORG1402)
    Yokoyama, T.
    Yoshioka, H.
    Fujimoto, D.
    Demura, Y.
    Hirano, K.
    Kawai, T.
    Kagami, R.
    Ishida, T.
    Tomii, K.
    Akai, M.
    Hirabayashi, M.
    Nishimura, T.
    Nakahara, Y.
    Kim, Y. H.
    Yoshimura, K.
    Hirai, T.
    ANNALS OF ONCOLOGY, 2019, 30
  • [47] Phase I/II Study of Volasertib (BI 6727), an Intravenous Polo-Like Kinase (Plk) Inhibitor, in Patients with Acute Myeloid Leukemia (AML): Results From the Randomized Phase II Part for Volasertib in Combination with Low-Dose Cytarabine (LDAC) Versus LDAC Monotherapy in Patients with Previously Untreated AML Ineligible for Intensive Treatment
    Maertens, Johan
    Luebbert, Michael
    Fiedler, Walter
    Fouillard, Loic
    Haaland, Alf
    Brandwein, Joseph M.
    Lepretre, Stephane
    Reman, Oumedaly
    Turlure, Pascal
    Bug, Gesine
    Mueller-Tidow, Carsten
    Kraemer, Alwin
    Voss, Florian
    Taube, Tillmann
    Fritsch, Holger
    Doehner, Hartmut
    BLOOD, 2012, 120 (21)
  • [48] LMS-02: A phase II single-arm multicenter study of doxorubicin in combination with trabectedin as a first-line treatment of advanced uterine leiomyosarcoma (u-LMS) and soft tissue LMS (ST-LMS): First results in patients with u-LMS.
    Pautier, Patricia
    Floquet, Anne
    Cupissol, Didier
    Lacas, Benjamin
    Bompas, Emmanuelle
    Chevreau, Christine
    Selle, Frederic
    Weber, Beatrice E.
    Guillemet, Cecile
    Penel, Nicolas
    Duffaud, Florence
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [49] Low-dose fludarabine and cyclophosphamide combined with rituximab in the first-line treatment of elderly/comorbid patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL): long-term results of project Q-lite by the Czech CLL Study Group
    Smolej, Lukas
    Brychtova, Yvona
    Cmunt, Eduard
    Doubek, Michael
    Spacek, Martin
    Belada, David
    Simkovic, Martin
    Stejskal, Lukas
    Zygulova, Irena
    Urbanova, Renata
    Brejcha, Martin
    Zuchnicka, Jana
    Mocikova, Heidi
    Kozak, Tomas
    BRITISH JOURNAL OF HAEMATOLOGY, 2021, 193 (04) : 769 - 778
  • [50] Study Design and Rationale for the PACE-LUNG Trial: A Multicenter, Single-Arm, Phase II Clinical Trial Evaluating the Efficacy of Additional Chemotherapy for Patients with EGFRm NSCLC with the Continued Presence of Plasma ctDNA EGFRm at Week 3 After Start of Osimertinib First-Line Treatment
    Acker, Fabian
    Aguinarte, Lukas
    Althoff, Friederike
    Heinzen, Sophie
    Rost, Maximilian
    Wild, Peter
    Reiser, Lena
    Manz, Martin
    Meyer, Frauke
    Stratmann, Jan
    Sebastian, Martin
    CLINICAL LUNG CANCER, 2022, 23 (07) : E473 - E477