Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains

被引：14
|
作者：
Chen, Xiao-zhuo
Xu, Peng
Liu, Lu
Zheng, Dan
Lei, Ping-sheng [1 ]
机构：
[1] Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Ketolide; Sulfur contained alkyl side chain; Antibacterial activity; Macrolide-resistant strain; Synthesis; MACROLIDE; ANTIBIOTICS; DERIVATIVES;
D O I：
10.1016/j.ejmech.2010.11.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：208 / 217
页数：10
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