SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF TYROSOL AND ITS STRUCTURAL ANALOGS

被引：3
|
作者：
Krysin, A. P. [1 ]
Tolstikova, T. G. [1 ]
Dolgikh, M. P. [1 ]
Shul'ts, E. E. [1 ]
Pokrovskii, L. M. [1 ]
机构：
[1] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 52卷 / 11期
关键词：
p-tyrosol; hydroxyalkylphenols; anti-inflammatory and antiulcer activity; SAFETY;
D O I：
10.1007/s11094-019-01924-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert-butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti-inflammatory activity. Pronounced antiulcer activity was found for p-tyrosol.
引用
收藏
页码：907 / 911
页数：5
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