Site-Selective 1,4-Difunctionalization of Nitrogen Heteroaromatics for Constructing Vinylidene Heterocycles

被引：9
|
作者：
He, Qianlin [1 ]
Zhong, Mingli [2 ]
Chen, Zhichao [1 ]
Liao, Chuyi [1 ]
Xie, Feng [1 ]
Zhu, Zhongzhi [1 ]
Chen, Xiuwen [1 ]
机构：
[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
[2] Guilin Med Univ, Coll Pharm, Guilin 541199, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 02期
关键词：
A one-pot; dearomatization; N-heteroaromatics; difunctionalization; NUCLEOPHILIC DEAROMATIZATION; PYRIDINES; METAL; ARYLATION;
D O I：
10.1002/adsc.202101098
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A one-pot protocol for constructing 1,4-difunctionalized quinoline/pyridine derivatives via the reaction of N-heteroaromatics, alkyl halides, and active methylene/methyl compounds was developed. The transformation involves dearomative functionalization of an in situ-activated N-heteroaromatic to construct new C-N and C=C bonds. This reaction has a broad substrate scope and functional group tolerance.
引用
收藏
页码：459 / 463
页数：5
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