Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of N-Acyl Propiolamides

被引：26
|
作者：
He, Yan [1 ]
Wang, Yingchun [2 ]
Liang, Xinping [1 ]
Huang, Bin [1 ]
Wang, Hengshan [1 ]
Pan, Ying-Ming [1 ]
机构：
[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
[2] Jishou Univ, Coll Chem & Chem Engn, Jishou 416000, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 22期
基金：
中国国家自然科学基金;
关键词：
TERMINAL ALKYNES; AMINOCARBONYLATION; AMINES; AMIDE; FUNCTIONALIZATION; CARBONYLATION; HETEROCYCLES; DERIVATIVES; ISONITRILE; FORMAMIDES;
D O I：
10.1021/acs.orglett.8b03068
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed three-component reactions between terminal alkynes, isonitriles, and sodium carboxylates have been developed. This novel and operationally simple methodology provides an alternative for the synthesis of N-acyl propiolamide derivatives under mild conditions using isonitriles as the amine source and sodium carboxylates as the oxygen and acyl source.
引用
收藏
页码：7117 / 7120
页数：4
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