Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum

被引：44
|
作者：
Zou, J
Jin, DZ
Chen, WL
Wang, J
Liu, QF
Zhu, XZ [1 ]
Zhao, WM
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Pharmacol, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Nat Prod, Shanghai 201203, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 10期
关键词：
D O I：
10.1021/np0502342
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC50 = 2.99 and 1.80 mu M) in vitro.
引用
收藏
页码：1514 / 1518
页数：5
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