Copper-catalyzed redox neutral ketoalkylation of Csp2-H bonds via C-C bond cleavage

被引：11

作者：

Chen, He

Guo, Li-Na

Sun, Qing-Xin

Chen, Lei

Tao, Jing-Qi

Gao, Pin ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Xian Key Lab Sustainable Energy Mat Chem, Sch Chem, Dept Chem, Xian 710049, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 20期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

HETEROAROMATIC N-OXIDES; CYCLOALKYLSILYL PEROXIDES; H FUNCTIONALIZATION; ALKYLATION; INHIBITORS; QUINOXALIN-2(1H)-ONES; DERIVATIVES; CYCLIZATION; QUINONES; RADICALS;

D O I：

10.1039/d1qo00882j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed ketoalkylation of Csp(2)-H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C-C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1H)-ones, heteroaromatic N-oxides and quinones with moderate to good yields.

引用

页码：5866 / 5871

页数：6

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