5-hydroxy-7-(4′-hydroxy-3′-methoxyphenyl)-1-phenyl-3-heptanone:: A pancreatic lipase inhibitor isolated from Alpinia officinarum

被引：35
|
作者：
Shin, JE
Han, MJ
Song, MC
Baek, NI
Kim, DH
机构：
[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea
[2] Kyung Hee Univ, Dept Food Sci, Seoul 130701, South Korea
[3] Kyung Hee Univ, Grad Sch Biotechnol, Seoul 130701, South Korea
[4] Kyung Hee Univ, PMRC, Seoul 130701, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 01期
关键词：
Apinia officinarum; pancreatic lipase; antihyperlipidemic activity; 5-hydroxy-7-(4 '-hydroxy-3 '-methoxyphenyl)-1-phenyl-3-heptanone;
D O I：
10.1248/bpb.27.138
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A pancreatic lipase inhibitor, 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (HPH), from the rhizome of Alpinia officinarum (AO) was isolated and its antihyperlipidemic activity was measured. HPH inhibited a pancreatic lipase with an IC50 value of 1.5 mg/ml (triolein as a substrate). HPH significantly lowered the serum TG level in corn oil feeding-induced triglyceridemic mice, and reduced serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, HPH did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. Based on these findings, we propose that PL inhibitors may be effective as hypolipidemic agents.
引用
收藏
页码：138 / 140
页数：3
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