Light-Induced PEGylation and Functionalization of Semiconductor Polymer Dots

被引:11
|
作者
Chen, Haobin [1 ,2 ]
Zhou, Hua [1 ]
Men, Xiaoju [2 ]
Sun, Kai [1 ,2 ]
Sun, Zezhou [1 ]
Fang, Xiaofeng [2 ]
Wu, Changfeng [2 ]
机构
[1] Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Jilin, Peoples R China
[2] Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
来源
CHEMNANOMAT | 2017年 / 3卷 / 10期
基金
中国国家自然科学基金;
关键词
polymer dots; cell labeling; fluorescent nanoparticles; functionalization; self-assembly; HIGHLY LUMINESCENT; NANOPARTICLES; THERAPY; FLUORESCENCE; ULTRABRIGHT; ATTACHMENT; MEDICINE;
D O I
10.1002/cnma.201700140
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A semiconductor polymer with side-chain oxetane groups was synthesized to form highly fluorescent, functionalized, and ultra-stable polymer dots (Pdots). A facile light-induced strategy covalently links functional polyethylene glycol (PEG) molecules to polymer dots while simultaneously providing functional groups for bioconjugation. The influence of photo-crosslinkable side-chains and PEG molecules on the properties and performance of Pdots was systematically investigated. The Pdots functionalized by photo-crosslinking show specific labeling and negligible non-specific binding as compared to non-functionalized Pdots. The results provide a viable strategy for nanoparticle assembly and functionalization.
引用
收藏
页码:755 / 759
页数:5
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