Real-time protein binding detection with neuromorphic integrated sensor

Real time protein binding interactions between biotinylated bovine serum albumen (BSA) and streptavidin (SA) are detected using chemoreceptive neuron MOS (CvMOS) transistors with extended floating gate structures. This enables protein interaction events to be monitored by a sensing gate area that is only capacitively coupled to the sensing circuits and far removed from the active area, reducing the invasiveness without loss of sensitivity. The use of both sensing and control gates to control the floating gate potential eliminates the need of an analyte reference electrode.