A systematic approach, referred to as function-oriented material design (FOMD), is illustrated in this keynote lecture, which can be used to design innovative advanced structures and materials for the specific tasks demanded of future automotive vehicles and other mechanical systems. In order to carry out the FOMD process, first the functions of a structure in the vehicle system need to be explicitly defined in a systematic way. Then these functions must be quantified, so as to defined the objective and constraint functions in the optimization process. Finally, an advanced optimization process needs to be carried out, and the material layout has to be finalized by the design engineer. Typically a number of constraints, such as manufacturing and cost constraints, need to be considered in the optimal material design process. Several example applications are considered in this lecture in order to illustrate how the technique can be used to ameliorate the optimization process for producing improved, cost-effective, and manufacturable structures and engineered materials.