Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury

被引：5
|
作者：
Kim, Mijeong [3 ]
Hwang, In Young [1 ]
Lee, Je-Hyuk [2 ]
Son, Kun Ho [4 ]
Jeong, Choon-Sik [1 ]
Jung, Joohee [1 ]
机构：
[1] Duksung Womens Univ, Coll Pharm, Seoul 132714, South Korea
[2] Duksung Womens Univ, Plant Resources Res Inst, Seoul 132714, South Korea
[3] Seoul Natl Univ, Sch Publ, Seoul 151742, South Korea
[4] Andong Natl Univ, Dept Food Sci & Nutr, Andong 760749, Gyeongbuk, South Korea
来源：
JOURNAL OF HEALTH SCIENCE | 2011年 / 57卷 / 03期
关键词：
Cimicifuga heracleifolia; anti-helicobacter pylori; gastric protection; ferulic acid; caffeic acid; HELICOBACTER-PYLORI ERADICATION; VITAMIN-C; CANCER; ACID; INFECTION; RACEMOSA;
D O I：
10.1248/jhs.57.289
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Cimicifuga heracleifolia (CH) ethanol extract and its constituents such as ferulic acid, caffeic acid, 24-epi-7,8-didehydrocimigenol-3-xyloside, and 23-O-acetylshengmanol 3-xyloside were investigated for their abilities to prevent gastric injury. To elucidate their gastric-protective effects, we assessed 1,1-diphenyl-2-picrylhydrazyl radical-radical scavenging activity and inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Ferulic acid and caffeic acid exhibited higher free radical scavenging activity than other constituents and inhibited the colonization of H. pylori effectively. Furthermore, 24-epi-7,8-didehydrocimigenol-3-xyloside and 23-O-acetylshengmanol-3-xyloside showed cytotoxicity in gastric cancer cells (SNU638 and AGS cells). These results suggest the novel activities of CH ethanol extract and its constituents. CH ethanol extract and its constituents could be utilized for the treatment and/or prevention of gastric injury.
引用
收藏
页码：289 / 292
页数：4
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