Pathogenesis of RSV lower respiratory tract infection: implications for vaccine development

被引：43
|
作者：
Brandenburg, AH
Neijens, HJ
Osterhaus, ADME
机构：
[1] Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands
[2] Sophia Childrens Hosp, Dept Pediat, Rotterdam, Netherlands
[3] Publ Hlth Lab Friesland, Leeuwarden, Netherlands
来源：
VACCINE | 2001年 / 19卷 / 20-22期
关键词：
RSV; pathogenesis; T cell; immune response;
D O I：
10.1016/S0264-410X(00)00536-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Respiratory syncytial virus (RSV) infection is the most prevalent cause of severe respiratory disease in infants. It also causes considerable morbidity in older children and adults with underlying risk factors. RSV vaccine development has been complicated by the need to administer the vaccine at a very young age and by enhanced disease observed after vaccination with formalin inactivated RSV. For infants live attenuated vaccines, which may not be expected to predispose for vaccine induced enhanced pathology, hold the greatest promise. However, the balance between attenuation and immunogenicity appears to be delicate. For older risk groups, results with subunit vaccines are most promising. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2769 / 2782
页数：14
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