Peering deeply inside the branch

被引:5
|
作者
Cai, Liang [1 ,2 ]
Bear, James E. [1 ,2 ]
机构
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Cell Biol & Dev Biol, Chapel Hill, NC 27599 USA
来源
JOURNAL OF CELL BIOLOGY | 2008年 / 180卷 / 05期
关键词
D O I
10.1083/jcb.200802062
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The actin-related protein 2/3 (Arp2/3) story has captivated the cytoskeleton community for over a decade. Not only does this complex nucleate new actin. laments, but it also anchors them into a dendritic meshwork that is used in many cellular contexts such as lamellipodial protrusion, endosome rocketing, and the movement of pathogens. One key piece of this puzzle that has been missing is a detailed structure of the Arp2/3-actin branch. Using electron tomography and computational docking, Rouiller et al. (Rouiller, I., X.-P. Xu, K.J. Amann, C. Egile, S. Nickell, D. Nicastro, R. Li, T.D. Pollard, N. Volkmann, and D. Hanein. 2008. J. Cell Biol. 180:887-895) present an elegant and intriguing structure of the Arp2/3 complex-mediated actin branch.
引用
收藏
页码:853 / 855
页数:3
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