Ecofriendly and sustainable efficient synthesis of bis(indolyl)methanes based on recyclable Bronsted (CSA) or Lewis (ZrOCl2•8H2O) acid catalysts

被引：0
|
作者：
Mishra, Santa [1 ]
Ghosh, Rina [1 ]
机构：
[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2011年 / 50卷 / 11期
关键词：
ZrOCl(2 center dot)8H(2)O; CSA; bis(indolyl)methane; indole; ALIPHATIC CARBOXYLIC-ACIDS; CARBONYL-COMPOUNDS; ELECTROPHILIC SUBSTITUTION; BIS-INDOLYLMETHANES; PRACTICAL SYNTHESIS; INDOLES; ZROCL2-CENTER-DOT-8H(2)O; CHLORIDE; CONDENSATION; ALDEHYDES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, highly efficient, environmentally benign synthesis of bis(indolyl)methanes and bis(indolyl)glycoconjugate by electrophilic substitution reaction of indole or methylindoles with a variety of aldehydes or simple ketones catalysed by 5 mol% of camphor sulphonic acid (CSA) or zirconium oxychloride octahydrate (ZrOCl(2 center dot)8H(2)O) in aqueous medium (20% EtOH-H(2)0) at ambient temperature is reported. The reactions also proceed efficiently with recovered catalyst (CSA or ZrOCl(2 center dot)8H(2)O) and under scale-up condition.
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页码：1630 / 1636
页数：7
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