Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties

被引：8

作者：

Chikalovets, Irina ^{[1
,2
]}

Filshtein, Alina ^{[1
]}

Molchanova, Valentina ^{[1
]}

Mizgina, Tatyana ^{[1
,2
]}

Lukyanov, Pavel ^{[1
]}

Nedashkovskaya, Olga ^{[1
]}

Hua, Kuo-Feng ^{[3
,4
]}

Chernikov, Oleg ^{[1
]}

机构：

[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia

[2] Far Eastern Fed Univ, Sch Nat Sci, Vladivostok 690950, Russia

[3] Natl Ilan Univ, Dept Biotechnol & Anim Sci, Ilan 260, Taiwan

[4] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pathol, Taipei 114, Taiwan

来源：

MOLECULES | 2020年 / 25卷 / 01期

关键词：

lectin; mussel; Gal-specific; mytilectin family; carbohydrate specificity; Crenomytilus grayanus; Mytilus trossulus; MUSSEL CRENOMYTILUS-GRAYANUS; GALNAC/GAL-SPECIFIC LECTIN; BURKITTS-LYMPHOMA CELLS; MOLECULAR-BASIS; EXPRESSION; ANTIGEN; RECEPTORS; GALACTOSE; GALECTIN; DOMAIN;

D O I：

10.3390/molecules25010150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels Crenomytilus grayanus and Mytilus trossulus. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-1, formed a novel lectin family, adopting beta-trefoil fold. In this mini review we discuss the structure, oligomerization, and carbohydrate-binding properties of a novel lectin family. We describe also the antibacterial, antifungal, and antiproliferative activities of these lectins and report about dependence of activities on molecular properties. Summarizing, CGL, MTL, and MytiLec-1 could be involved in the immunity in mollusks and may become a basis for the elaboration of new diagnostic tools or treatments for a variety of cancers.

引用

页数：15

共 50 条

[41] A single mutation reforms the binding activity of an adhesion-deficient family 3 carbohydrate-binding module
Yaniv, Oren
Petkun, Svetlana
Shimon, Linda J. W.
Bayer, Edward A.
Lamed, Raphael
Frolow, Felix
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2012, 68 : 819 - 828
[42] Function and structure correlation between family 20 and 21 carbohydrate-binding modules in glucoamylase
Lin, Shu-Chuan
Chou, Wei-I
Chang, Margaret Dah-Tsyr
GLYCOBIOLOGY, 2006, 16 (11) : 1127 - 1127
[43] Solution structure of family 21 carbohydrate-binding module from Rhizopus oryzae glucoamylase
Liu, Yu-Nan
Lai, Yen-Ting
Chou, Wei-I
Chang, Margaret Dah-Tsyr
Lyu, Ping-Chiang
BIOCHEMICAL JOURNAL, 2007, 403 (01) : 21 - 30
[44] Studies by site-directed mutagenesis of the carbohydrate-binding properties of a bark lectin from Robinia pseudoacacia
Nishiguchi, M
Yoshida, K
Sumizono, T
Tazaki, K
FEBS LETTERS, 1997, 403 (03) : 294 - 298
[45] Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39
Fusetti, F
Pijning, T
Kalk, KH
Bos, E
Dijkstra, BW
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) : 37753 - 37760
[46] Carbohydrate-Binding Properties and Antimicrobial and Anticancer Potential of a New Lectin from the Phloem Sap of Cucurbita pepo
Islam, Md. Aminul
Hossain, Md. Mikail
Khanam, Alima
Asaduzzaman, A. K. M.
Kabir, Syed Rashel
Ozeki, Yasuhiro
Fujii, Yuki
Hasan, Imtiaj
MOLECULES, 2024, 29 (11):
[47] Structure and Ligand-Binding Properties of the O Antigen ABC Transporter Carbohydrate-Binding Domain
Bi, Yunchen
Zimmer, Jochen
STRUCTURE, 2020, 28 (02) : 252 - +
[48] Crystal structure of a family 54 α-L-arabinofuranosidase reveals a novel carbohydrate-binding module that can bind arabinose
Miyanaga, A
Koseki, T
Matsuzawa, H
Wakagi, T
Shoun, H
Fushinobu, S
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (43) : 44907 - 44914
[49] SOLUBLE CARBOHYDRATE-BINDING ACTIVITY FROM RAT TISSUES
LIPITZ, L
KELLY, A
DRUYAN, R
JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1971, 78 (05): : 829 - &
[50] Carbohydrate-binding specificity of a fucose-specific lectin from Aspergillus oryzae
Matsumura, K
Higashida, K
Ishida, H
Hata, Y
Kawato, A
Abe, Y
Kato, M
Ueda, M
Yamamoto, K
GLYCOBIOLOGY, 2004, 14 (11) : 1092 - 1092

← 1 2 3 4 5 →