Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties

被引：8

作者：

Chikalovets, Irina ^{[1
,2
]}

Filshtein, Alina ^{[1
]}

Molchanova, Valentina ^{[1
]}

Mizgina, Tatyana ^{[1
,2
]}

Lukyanov, Pavel ^{[1
]}

Nedashkovskaya, Olga ^{[1
]}

Hua, Kuo-Feng ^{[3
,4
]}

Chernikov, Oleg ^{[1
]}

机构：

[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia

[2] Far Eastern Fed Univ, Sch Nat Sci, Vladivostok 690950, Russia

[3] Natl Ilan Univ, Dept Biotechnol & Anim Sci, Ilan 260, Taiwan

[4] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pathol, Taipei 114, Taiwan

来源：

MOLECULES | 2020年 / 25卷 / 01期

关键词：

lectin; mussel; Gal-specific; mytilectin family; carbohydrate specificity; Crenomytilus grayanus; Mytilus trossulus; MUSSEL CRENOMYTILUS-GRAYANUS; GALNAC/GAL-SPECIFIC LECTIN; BURKITTS-LYMPHOMA CELLS; MOLECULAR-BASIS; EXPRESSION; ANTIGEN; RECEPTORS; GALACTOSE; GALECTIN; DOMAIN;

D O I：

10.3390/molecules25010150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels Crenomytilus grayanus and Mytilus trossulus. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-1, formed a novel lectin family, adopting beta-trefoil fold. In this mini review we discuss the structure, oligomerization, and carbohydrate-binding properties of a novel lectin family. We describe also the antibacterial, antifungal, and antiproliferative activities of these lectins and report about dependence of activities on molecular properties. Summarizing, CGL, MTL, and MytiLec-1 could be involved in the immunity in mollusks and may become a basis for the elaboration of new diagnostic tools or treatments for a variety of cancers.

引用

页数：15

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