Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy

被引：0
|
作者：
Yang Yong-guang [2 ]
Liu Du [2 ]
Xia Yu [2 ]
Zhou Yan-hui [2 ]
Zhong Xue-yun [1 ]
Liu Jie [2 ]
机构：
[1] Jinan Univ, Coll Med, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2011年 / 27卷 / 03期
基金：
中国国家自然科学基金;
关键词：
PLGA-mPEG nanoparticle; NAMI-A; Drug release; Drug delivery; Antitumor; DELIVERY; CISPLATIN; EFFICIENCY; COMPLEXES; POLYMERS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
NAMI-A[imidazolium trans-tetrachloro(dimethylsulfoxide)imidazoleruthenium(III)]. shows extraordinary activities against metastatic tumors. However, the hydrolysis of NAMI-A to produce dimethyl sulfoxide(DMSO) could reduce anti-metastatic activity. To enhance the circulation time and the anti-metastatic effect of NAMI-A, NAMI-A-loaded nanoparticles were prepared by the double emulsion method and characterized by scanning electron microscopy for surface morphology, laser light scattering rot size and zeta potential for surface charges. Controlled release of NAMI-A was observed in a sustained manner. Compared with free NAMI-A, NAMI-A-loaded nanoparticles exhibited superior antitumor effect by delaying tumor growth in T739 mice. PLGA-mPEG nanoparticles are promising for further studies as drug delivery carriers.
引用
收藏
页码：345 / 349
页数：5
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