Synthesis of α-Ketone-isoquinoline Derivatives via Tandem Ruthenium(II)-Catalyzed C-H Activation and Annulation

被引：31
|
作者：
Wu, Xiao-Lin [1 ]
Dong, Lin [1 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 22期
关键词：
PALLADIUM-CATALYZED IMINOANNULATION; AROMATIC KETIMINES; CARDIOTONIC AGENTS; ALKYNES; PYRIDINES; 4-AROYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES; BENZYLAMINES; CYCLIZATION; QUINOLINES; ACYLATION;
D O I：
10.1021/acs.orglett.8b02759
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new ruthenium(II)-catalyzed tandem C-H activation/cyclization/hydrolysis cascade process of 2H-imidazoles and alkynes for facile and regioselective access to alpha-ketone-isoquinolines has been successfully developed. 2H-Imidazole as the novel traceless directing group has been well applied in this paper. The protocol features mild reaction conditions and easily accessible starting materials, and alpha-ketone-isoquinolines could be applied to further construct more complex heterocyclic compounds.
引用
收藏
页码：6990 / 6993
页数：4
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