Nickel-Catalyzed Reductive Cross-Coupling of Benzyl Chlorides with Aryl Chlorides/Fluorides: A One-Pot Synthesis of Diarylmethanes

被引：52

作者：

Zhang, Jie ^{[1
]}

Lu, Gusheng ^{[1
]}

Xu, Jin ^{[1
]}

Sun, Hongmei ^{[1
]}

Shen, Qj ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 12期

基金：

中国国家自然科学基金;

关键词：

IRON(III) AMINE-BIS(PHENOLATE) COMPLEXES; HETEROCYCLIC CARBENE LIGANDS; F BOND ACTIVATION; GRIGNARD-REAGENTS; ALKYL-HALIDES; ZINC REAGENTS; FUNCTIONALIZED DIARYLMETHANES; ARYLMAGNESIUM REAGENTS; ALLYLIC ACETATES; KETONE FORMATION;

D O I：

10.1021/acs.orglett.6b01134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first nickel-catalyzed, magnesium-mediated reductive cross-coupling between benzyl chlorides and aryl chlorides or fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields in a one-pot manner using easy-to-access mixed PPh3/NHC Ni(II) complexes of Ni(PPh3)(NHC)Br-2 (NHC = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, IPr, 1a; 1,3-di-tert-butylimidazol-2-ylidene, ItBu, 1b) as catalyst precursors. Activation of polychloroarenes or chemoselective cross-coupling based on the difference in catalytic activity between 1a and 1b is used to construct oligo-diarylmethane motifs.

引用

页码：2860 / 2863

页数：4

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