Correlation between E-cadherin and CD44 adhesion molecules expression and cervical lymph node metastasis in oral tongue SCC: Predictive significance or not

被引：23

作者：

Mostaan, Leila Vazifeh ^{[1
]}

Khorsandi, Mohammad Taghi ^{[2
]}

Sharifian, Shahriar-Mohammad Reza ^{[1
]}

Shandiz, Fatemeh Homee ^{[1
]}

Mirashrafi, Fatemeh ^{[2
]}

Sabzari, Homa ^{[1
]}

Badiee, Reza ^{[1
]}

Borghei, Hasti ^{[2
]}

Yazdani, Nasrin ^{[2
]}

机构：

[1] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[2] Univ Tehran Med Sci, Otorhinolaryngol Res Ctr, Tehran, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2011年 / 207卷 / 07期

关键词：

Tongue; Squamous cell carcinoma; Lymph node metastasis; E-cadherin; CD44; SQUAMOUS-CELL CARCINOMA; P-CADHERIN; SURVIVAL; MMP-9;

D O I：

10.1016/j.prp.2011.04.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The aim of this article was to evaluate the expression of E-cadherin and CD44 adhesion molecule in oral tongue squamous cell carcinoma (SCC) since inappropriate expression of adhesion molecules raises the metastatic ability of the tumor cells. Biopsy specimens from 92 patients with tongue SCC were examined for the expression of E-cadherin and CD44 by immunohistochemistry. The relationship of immunoreactivity with tumor stage and cervical lymph node metastasis was then analyzed. Sixty-one patients (66.3%) had reduced or negative staining for CD44. Weak or absent staining for E-cadherin was seen in 14 patients (15.21%). Cervical lymph node metastasis is associated with decreased or negative staining for CD44, but no association was found between E-cadherin immunoreactivity and nodal metastasis. Our study reveals that reduced expression of CD44 could be an indicator of high invasiveness of tumor by increasing cervical lymph node metastasis. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：448 / 451

页数：4

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