Water-soluble Bis(thiosemicarbazonato)copper(II) Complexes

被引：13

作者：

Buncic, Gojko ^{[1
,2
]}

Hickey, James L. ^{[1
,2
]}

Schieber, Christine ^{[1
,2
]}

White, Jonathan M. ^{[1
,2
]}

Crouch, Peter J. ^{[3
,4
]}

White, Anthony R. ^{[3
,4
]}

Xiao, Zhiguang ^{[1
,2
]}

Wedd, Anthony G. ^{[1
,2
]}

Donnelly, Paul S. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia

[3] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia

[4] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2011年 / 64卷 / 03期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

COPPER RADIOPHARMACEUTICALS; BIFUNCTIONAL CHELATORS; MECHANISM; LIGANDS; AGENT; SELECTIVITY; CU-64-ATSM; VERSATILE; BINDING; ZINC;

D O I：

10.1071/CH10463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of four new water-soluble bis(thiosemicarbazone) ligands and their copper(II) complexes is presented and their potential to be new ligands for copper radiopharmaceuticals is discussed. The ligands and complexes have been characterized by a combination of NMR spectroscopy, mass spectrometry, and X-ray crystallography. The electrochemical behaviour of two of the copper(II) complexes was investigated by cyclic voltammetry and revealed that both complexes exhibited a quasi-reversible redox process attributed to a Cu-II/Cu-I process. Two of the new ligands were radiolabelled with positron-emitting Cu-64 with a view to assessing their potential as ligands that bind radioactive copper isotopes for application in diagnostic radiopharmaceuticals. The cellular uptake of the copper complexes was investigated in SH-SY5Y cells.

引用

页码：244 / 252

页数：9

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