Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

被引：16
|
作者：
Xu, Wengang [1 ]
Li, Qingcui [1 ]
Cao, Chuanpeng [1 ]
Zhang, Fanglin [1 ]
Zheng, Hua [1 ]
机构：
[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Hubei, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 22期
基金：
中国国家自然科学基金;
关键词：
ONE-POT SYNTHESIS; BOND FORMATION; O-ARYLPHENOLS; IODINE; DIBENZOFURANS; CYCLIZATION; 2-ARYLBENZOFURANS; ACTIVATION; ANNULATION; INHIBITORS;
D O I：
10.1039/c5ob00577a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp(2))-H functionalization for the formation of C-O bond. This transformation is mediated by I-2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.
引用
收藏
页码：6158 / 6161
页数：4
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