Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel

被引：22

作者：

Maria Martin-Rojas, Reyes ^{[1
]}

Gomez-Centurion, Ignacio ^{[1
,2
]}

Bailen, Rebeca ^{[1
,2
]}

Bastos, Mariana ^{[1
,2
]}

Diaz-Crespo, Francisco ^{[2
,3
]}

Carbonell, Diego ^{[1
,2
]}

Correa-Rocha, Rafael ^{[2
]}

Pion, Marjorie ^{[2
]}

Munoz, Cristina ^{[1
,2
]}

Sancho, Milagros ^{[2
,4
]}

Gomez Fernandez, Isabel ^{[2
,5
]}

Oarbeascoa, Gillen ^{[1
,2
]}

Perez-Corral, Ana ^{[1
,2
]}

Martinez-Laperche, Carolina ^{[1
,2
]}

Anguita, Javier ^{[1
,2
]}

Buno, Ismael ^{[1
,2
,6
,7
]}

Menarguez, Javier ^{[2
,3
]}

Luis Diez-Martin, Jose ^{[1
,2
,7
]}

Kwon, Mi ^{[1
,2
]}

机构：

[1] Hosp Gen Univ Gregorio Maranon, Dept Hematol, Doctor Esquerdo 46, Madrid 28007, Spain

[2] Gregorio Maranon Hlth Res Inst, Madrid, Spain

[3] Hosp Gen Univ Gregorio Maranon, Dept Pathol, Madrid, Spain

[4] Hosp Gen Univ Gregorio Maranon, Intens Care Unit, Madrid, Spain

[5] Hosp Gen Univ Gregorio Maranon, Dept Nucl Med, Madrid, Spain

[6] Hosp Gen Univ Gregorio Maranon, Genom Unit, Madrid, Spain

[7] Univ Complutense Madrid, Madrid, Spain

来源：

CLINICAL CASE REPORTS | 2022年 / 10卷 / 01期

关键词：

CAR T cells; hemophagocytic lymphohistiocytosis; macrophage activation syndrome; tisagenlecleucel; T-CELL THERAPY; MANAGEMENT; DIAGNOSIS; EMAPALUMAB; CHILDREN;

D O I：

10.1002/ccr3.5209

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chimeric antigen receptor (CAR) T cell-related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR T-cell follow-up, allows a more precise management of this complication.

引用

页数：6

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