Polymer-caged lipsomes: A pH-Responsive delivery system with high stability

被引：196
|
作者：
Lee, Sang-Min [1 ]
Chen, Haimei [1 ]
Dettmer, Christine M. [1 ]
O'Halloran, Thomas V. [1 ]
Nguyen, Sonlinh T. [1 ]
机构：
[1] Northwestern Univ, Ctr Canc Nanotechnol Excellence, Dept Chem, Evanston, IL 60208 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 49期
关键词：
D O I：
10.1021/ja070748i
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2'-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.
引用
收藏
页码：15096 / +
页数：3
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