Synthesis, anti-inflammatory activity and molecular docking of 2-methyl-3-furamides

被引：7

作者：

Matiichuk, Yuliia ^{[1
]}

Ogurtsov, Volodymyr ^{[1
]}

Ostapiuk, Yuriy ^{[2
]}

Chaban, Taras ^{[1
]}

Matiychuk, Vasyl ^{[2
]}

机构：

[1] Danylo Halytsky Lviv Natl Med Univ, Pekarska 69, Lvov 79010, Ukraine

[2] Ivan Franko Natl Univ Lviv, 6 Kyryla & Mefodia, Lvov 79005, Ukraine

来源：

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2020年 / 10卷 / 04期

关键词：

organic synthesis; 2-methyl-3-furamides; molecular docking; anti-inflammatory activity; BIOLOGICAL-ACTIVITY; UNSATURATED-COMPOUNDS; ARYLATION PRODUCTS; CONVENIENT METHOD; DERIVATIVES; HETEROCYCLES; DESIGN; POTENT; DRUGS; QSAR;

D O I：

10.33263/BRIAC104.809814

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In an effort to develop novel anti-inflammatory agents, a series of novel 2-methyl-3-furamides were synthesized and modified.The structures of the obtained compounds were confirmed by H-1 NMR spectroscopy and elemental analysis.The synthesized compounds were preselected via molecular docking to be tested for their anti-inflammatory activity. Researched substances impact effect on the inflammation exudative phase course was studied on the basis of white rats paws inflammatory edema carrageenan model. Antiinflammatory activity researches have shown that synthesized compounds have possessed expressed anti-inflammatory properties, and some of them, in terms of activity, approach or exceed the comparison drug Ibuprofen.

引用

页码：5809 / 5814

页数：6

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