Color me sensitive: Amplification and discrimination in photonic silicon nanostructures

被引：45
|
作者：
Sailor, Michael J. [1 ]
机构：
[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
来源：
ACS NANO | 2007年 / 1卷 / 04期
关键词：
D O I：
10.1021/nn700340u
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new paper in this issue discusses some of the considerations for fabrication of biosensor devices in the porous silicon material system. The results focus on optical detection of p. rotease activity on specific substrates that have been immobilized in a porous silicon matrix. Solutions to important limitations of porous microsensors are presented: stabilizing the sensor against corrosion-induced zero point drift, minimizing the effects of nonspecific protein binding, and enhancing the optical response by incorporation of a catalytic reaction in the sensing scheme.
引用
收藏
页码：248 / 252
页数：5
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