Phospholamban inhibits Ca2+ pump oligomerization and intersubunit free energy exchange leading to activation of cardiac muscle SERCA2a

被引：7
|
作者：
Mahaney, JE [1 ]
Albers, RW
Kutchai, H
Froehlich, JP
机构：
[1] W Virginia Univ, Dept Biochem, Morgantown, WV 26506 USA
[2] NINDS, NIH, Bethesda, MD 20892 USA
[3] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
[4] NIA, NIH, Baltimore, MD 21224 USA
来源：
NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS | 2003年 / 986卷
关键词：
cardiac muscle sarcoplasmic reticulum; phospholamban; SERCA2a; oligomerization; free energy exchange;
D O I：
10.1111/j.1749-6632.2003.tb07208.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：338 / 340
页数：3
相关论文
共 50 条
  • [31] Decreased binding of protein kinase a phosphorylated phospholamban (P-PLB) to the cardiac Ca2+PUMP (SERCA2a) revealed by use of cross-linking reagents
    Chen, Zhenhui
    Akin, Brandy L.
    Jones, Larry R.
    BIOPHYSICAL JOURNAL, 2007, : 8A - 9A
  • [32] Calcium cycling proteins of the cardiac sarcoplasmic reticulum -: Molecular regulation of the phospholamban-SERCA Ca2+ pump system and its pathophysiological consequences
    Tada, M
    CIRCULATION JOURNAL, 2003, 67 (09) : 729 - 737
  • [33] Overexpression of the Ca2+ cycling protein SERCA2a in transgenic rats improves diastolic cardiac performance in experimental hypothyroidism
    Rehfeld, U
    Reissfelder, C
    Paul, M
    Vetter, R
    HYPERTENSION, 2003, 42 (04) : 636 - 636
  • [34] Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy
    Nakayama, H
    Otsu, K
    Yamaguchi, O
    Nishida, K
    Date, MO
    Hongo, K
    Kusakari, Y
    Toyofuku, T
    Hikoso, S
    Kashiwase, K
    Takeda, T
    Matsumura, Y
    Kurihara, S
    Hori, M
    Tada, M
    FASEB JOURNAL, 2002, 16 (13): : 61 - +
  • [35] Pi inhibits the SR Ca2+ pump and stimulates pump-mediated Ca2+ leak in rabbit cardiac myocytes
    Smith, GL
    Duncan, AM
    Neary, P
    Bruce, L
    Burton, FL
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 279 (02): : H577 - H585
  • [36] Relationship between phospholamban and nucleotide activation of cardiac sarcoplasmic reticulum Ca2+ adenosinetriphosphatase
    Coll, KE
    Johnson, RG
    McKenna, E
    BIOCHEMISTRY, 1999, 38 (08) : 2444 - 2451
  • [37] Ca2+ exchange with troponin C and cardiac muscle dynamics
    Davis, Jonathan P.
    Tikunova, Svetlana B.
    CARDIOVASCULAR RESEARCH, 2008, 77 (04) : 619 - 626
  • [38] A Phospholamban-Cardiac Ca2+ Pump Fusion Protein Retains Full Functional Regulation
    Chen, Zhenhui
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 169A - 169A
  • [39] Improving cardiac Ca2+ transport into the sarcoplasmic reticulum in heart failure: lessons from the ubiquitous SERCA2b Ca2+ pump
    Vangheluwe, Peter
    Wuytack, Frank
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2011, 39 : 781 - 787
  • [40] The Allosteric Coupling of the Cytoplasmic Phosphorylation and Transmembrane Domain Deocclusion in the Ca2+ SERCA Pump Elucidated by Free Energy Simulations
    Rui, Huan
    Das, Avisek
    Roux, Benoit
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 148A - 148A
12345