Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies

被引：96

作者：

Rampes, Sanketh ^{[1
]}

Ma, Daqing ^{[2
]}

机构：

[1] Kings Coll London, Fac Life Sci & Med, London SE1 1U, England

[2] Imperial Coll London, Chelsea & Westminster Hosp, Fac Med, Anaesthet Pain Med & Intens Care,Dept Surg & Canc, London SW10 9NH, England

来源：

JOURNAL OF BIOMEDICAL RESEARCH | 2019年 / 33卷 / 04期

关键词：

liver transplantation; reperfusion injury; mechanism; therapeutics; ischemic preconditioning; MITOCHONDRIAL PERMEABILITY TRANSITION; HYPOTHERMIC MACHINE PRESERVATION; SELECTIN GLYCOPROTEIN LIGAND-1; PAN-CASPASE INHIBITOR; ISCHEMIA/REPERFUSION INJURY; NITRIC-OXIDE; EX-VIVO; REACTIVE OXYGEN; N-ACETYLCYSTEINE; OXIDATIVE STRESS;

D O I：

10.7555/JBR.32.20180087

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of increasing significance due to increased use of expanded criteria livers for transplantation. This review summarizes the mechanisms and protective strategies for hepatic ischemia-reperfusion injury in the context of liver transplantation. Pharmacological therapies, the use of pre-and post-conditioning and machine perfusion are discussed as protective strategies. The use of machine perfusion offers significant potential in the reconditioning of liver grafts and the prevention of hepatic ischemia-reperfusion injury, and is an exciting and active area of research, which needs more study clinically.

引用

页码：221 / 234

页数：14

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