Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies

被引：96
|
作者：
Rampes, Sanketh [1 ]
Ma, Daqing [2 ]
机构：
[1] Kings Coll London, Fac Life Sci & Med, London SE1 1U, England
[2] Imperial Coll London, Chelsea & Westminster Hosp, Fac Med, Anaesthet Pain Med & Intens Care,Dept Surg & Canc, London SW10 9NH, England
来源：
JOURNAL OF BIOMEDICAL RESEARCH | 2019年 / 33卷 / 04期
关键词：
liver transplantation; reperfusion injury; mechanism; therapeutics; ischemic preconditioning; MITOCHONDRIAL PERMEABILITY TRANSITION; HYPOTHERMIC MACHINE PRESERVATION; SELECTIN GLYCOPROTEIN LIGAND-1; PAN-CASPASE INHIBITOR; ISCHEMIA/REPERFUSION INJURY; NITRIC-OXIDE; EX-VIVO; REACTIVE OXYGEN; N-ACETYLCYSTEINE; OXIDATIVE STRESS;
D O I：
10.7555/JBR.32.20180087
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of increasing significance due to increased use of expanded criteria livers for transplantation. This review summarizes the mechanisms and protective strategies for hepatic ischemia-reperfusion injury in the context of liver transplantation. Pharmacological therapies, the use of pre-and post-conditioning and machine perfusion are discussed as protective strategies. The use of machine perfusion offers significant potential in the reconditioning of liver grafts and the prevention of hepatic ischemia-reperfusion injury, and is an exciting and active area of research, which needs more study clinically.
引用
收藏
页码：221 / 234
页数：14
相关论文
共 50 条
  • [1] Hepatic ischemia-reperfusion injury in liver transplant setting:mechanisms and protective strategies
    Sanketh Rampes
    Daqing Ma
    The Journal of Biomedical Research, 2019, 33 (04) : 221 - 234
  • [2] The mechanisms and strategies to protect from hepatic ischemia-reperfusion injury
    Li, J.
    Li, R. -J.
    Lv, G. -Y.
    Liu, H. -Q.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2015, 19 (11) : 2036 - 2047
  • [3] Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide
    Guan, Lian-Yue
    Fu, Pei-Yao
    Li, Pei-Dong
    Li, Zhuo-Nan
    Liu, Hong-Yu
    Xin, Min-Gang
    Li, Wei
    WORLD JOURNAL OF GASTROINTESTINAL SURGERY, 2014, 6 (07): : 122 - 128
  • [4] Cellular mechanisms of hepatic ischemia-reperfusion injury
    Jaeschke, H
    7TH WORLD CONGRESS FOR MICROCIRCULATION, 2001, : 77 - 84
  • [5] Protective Effects of Quercetin on Hepatic Ischemia-Reperfusion Injury
    Bahadir, Halil Mert
    Sarigoz, Talha
    Topuz, Omer
    Sevim, Yusuf
    Ertan, Tamer
    Sarici, Inanc Samil
    ISTANBUL MEDICAL JOURNAL, 2018, 19 (01): : 47 - 51
  • [6] Hepatic Ischemia-reperfusion Injury: Protective Approaches and Treatment
    Singh, Kuldeep
    Gupta, Jeetendra Kumar
    Kuma, Shivendra
    Mukherjee, Soumyadip
    Patel, Aman
    CURRENT MOLECULAR PHARMACOLOGY, 2024, 17
  • [7] Hepatic Ischemia-reperfusion Injury: Protective Approaches and Treatment
    Singh, Kuldeep
    Gupta, Jeetendra Kumar
    Kuma, Shivendra
    Anurag
    Mukherjee, Soumyadip
    Patel, Aman
    CURRENT MOLECULAR PHARMACOLOGY, 2024, 17
  • [8] Protective effects of sevoflurane in hepatic ischemia-reperfusion injury
    Li, Ji
    Yuan, Tong
    Zhao, Xin
    Lv, Guo-Yue
    Liu, Huan-Qiu
    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2016, 29 (02): : 300 - 307
  • [9] Ischemia-reperfusion injury of the intestine and protective strategies against injury
    Mallick, IH
    Yang, WX
    Winslet, MC
    Seifalian, AM
    DIGESTIVE DISEASES AND SCIENCES, 2004, 49 (09) : 1359 - 1377
  • [10] Molecular mechanisms contributing to the protective effect of levosimendan in liver ischemia-reperfusion injury
    Ibrahim, Mohamed A.
    Abdel-Gaber, Seham A.
    Amin, Entesar F.
    Ibrahim, Salwa A.
    Mohammed, Rehab K.
    Abdelrahman, Aly M.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 741 : 64 - 73
12345