Imagery of voluntary movement of fingers, toes, and tongue activates corresponding body-part-specific motor representations

被引:457
作者
Ehrsson, HH
Geyer, S
Naito, E
机构
[1] Karolinska Inst, Dept Neurosci, Div Human Brain Res, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Woman & Child Hlth, Motor Control Lab, S-17176 Stockholm, Sweden
[3] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-40225 Dusseldorf, Germany
关键词
D O I
10.1152/jn.01113.2002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigate whether imagery of voluntary movements of different body parts activates somatotopical sections of the human motor cortices. We used functional magnetic resonance imaging to detect the cortical activity when 7 healthy subjects imagine performing repetitive (0.5-Hz) flexion/extension movements of the right fingers or right toes, or horizontal movements of the tongue. We also collected functional images when the subjects actually executed these movements and used these data to define somatotopical representations in the motor areas. In this study, we relate the functional activation maps to cytoarchitectural population maps of areas 4a, 4p, and 6 in the same standard anatomical space. The important novel findings are 1) that imagery of hand movements specifically activates the hand sections of the contralateral primary motor cortex (area 4a) and the contralateral dorsal premotor cortex (area 6) and a hand representation located in the caudal cingulate motor area and the most ventral part of the supplementary motor area; 2) that when imagining making foot movements, the foot zones of the posterior part of the contralateral supplementary motor area (area 6) and the contralateral primary motor cortex (area 4a) are active; and 3) that imagery of tongue movements activates the tongue region of the primary motor cortex and the premotor cortex bilaterally (areas 4a, 4p, and 6). These results demonstrate that imagery of action engages the somatotopically organized sections of the primary motor cortex in a systematic manner as well as activating some body-part specific representations in the nonprimary motor areas. Thus the content of the mental motor image, in this case the body part, is reflected in the pattern of motor cortical activation.
引用
收藏
页码:3304 / 3316
页数:13
相关论文
共 98 条
[31]   How many subjects constitute a study? [J].
Friston, KJ ;
Holmes, AP ;
Worsley, KJ .
NEUROIMAGE, 1999, 10 (01) :1-5
[32]   Partially overlapping neural networks for real and imagined hand movements [J].
Gerardin, E ;
Sirigu, A ;
Lehéricy, S ;
Poline, JB ;
Gaymard, B ;
Marsault, C ;
Agid, Y ;
Le Bihan, D .
CEREBRAL CORTEX, 2000, 10 (11) :1093-1104
[33]   Areas 3a, 3b, and 1 of human primary somatosensory cortex - 2. Spatial normalization to standard anatomical space [J].
Geyer, S ;
Schormann, T ;
Mohlerg, H ;
Zilles, K .
NEUROIMAGE, 2000, 11 (06) :684-696
[34]   Two different areas within the primary motor cortex of man [J].
Geyer, S ;
Ledberg, A ;
Schleicher, A ;
Kinomura, S ;
Schormann, T ;
Burgel, U ;
Klingberg, T ;
Larsson, J ;
Zilles, K ;
Roland, PE .
NATURE, 1996, 382 (6594) :805-807
[35]  
GEYER S, 2002, SOC NEUR ABSTR
[36]   SOMATOTOPIC MAPPING OF THE PRIMARY MOTOR CORTEX IN HUMANS - ACTIVATION STUDIES WITH CEREBRAL BLOOD-FLOW AND POSITRON EMISSION TOMOGRAPHY [J].
GRAFTON, ST ;
WOODS, RP ;
MAZZIOTTA, JC ;
PHELPS, ME .
JOURNAL OF NEUROPHYSIOLOGY, 1991, 66 (03) :735-743
[37]   Functional properties of brain areas associated with motor execution and imagery [J].
Hanakawa, T ;
Immisch, I ;
Toma, K ;
Dimyan, MA ;
Van Gelderen, P ;
Hallett, M .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (02) :989-1002
[38]   Functional mapping of human medial frontal motor areas - The combined use of functional magnetic resonance imaging and cortical stimulation [J].
Hanakawa, T ;
Ikeda, A ;
Sadato, N ;
Okada, T ;
Fukuyama, H ;
Nagamine, T ;
Honda, M ;
Sawamoto, N ;
Yazawa, S ;
Kunieda, T ;
Ohara, S ;
Taki, W ;
Hashimoto, N ;
Yonekura, Y ;
Konishi, J ;
Shibasaki, H .
EXPERIMENTAL BRAIN RESEARCH, 2001, 138 (04) :403-409
[39]  
HOLMES A, 1997, HUMAN BRAIN FUNCTION, P59
[40]   DISTRIBUTION OF CEREBRAL BLOOD-FLOW IN DOMINANT HEMISPHERE DURING MOTOR IDEATION AND MOTOR-PERFORMANCE [J].
INGVAR, DH ;
PHILIPSON, L .
ANNALS OF NEUROLOGY, 1977, 2 (03) :230-237