Role of IL-12 in HIV infection and vaccine

被引:14
|
作者
Villinger, Francois
Ansari, Aftab A. [1 ]
机构
[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
关键词
IL-12; immunotherapy; HIV; SIV; vaccine; HUMAN-IMMUNODEFICIENCY-VIRUS; INTERFERON-GAMMA-PRODUCTION; CD4(+) T-CELLS; IN-VITRO; INTERLEUKIN-12; PRODUCTION; IMMUNE-RESPONSES; RHESUS MACAQUES; HUMAN MONOCYTES; IFN-GAMMA; MICE;
D O I
10.1684/ecn.2010.0206
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Among cytokines that dictate the fate of developing immune responses, IL-12 represents an important nexus for the development of type I cell-mediated immune responses (CMI). This factor is primarily produced by monocytic cell lineages in response to stimuli such as pathogen-associated molecular patterns, dictating the development of naive T cells as they differentiate into antigen-specific T cells. HIV infection results in an early loss of effective TH1 prototype CMI when such responses appear to be precisely the type of CMI needed to control the virus and a host of opportunistic pathogens. Besides CD4 T cell loss, much of the muted IL-12 response has been attributed to direct effects of HIV or its proteins on antigen-presenting cells, while T and NK cell responses to IL-12 appear maintained during chronic HIV infection. However, while IL-12 therapy is unlikely to provide major benefits in the context of an established HIV infection, IL-12 preconditioning of monkeys during acute SIV infection markedly delayed disease progression. These findings suggest that IL-12 may serve as a critical vaccine adjuvant, and as treatment for particular opportunistic agents or neoplasm such as Kaposi's sarcoma; it has already shown promising results in the context of HIV infection.
引用
收藏
页码:215 / 218
页数:4
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