Dose distribution in boron neutron capture therapy for the treatment of brain cancer

被引：2

作者：

Pereira, Leandro O. ^{[1
]}

Freitas, Renato P. ^{[1
]}

Ferreira, Douglas S. ^{[1
]}

Felix, Valter S. ^{[1
]}

Goncalves, Elicardo A. S. ^{[1
]}

Pimenta, Andre R. ^{[1
]}

Dutra, Rafael de Sousa ^{[1
]}

da Silva, Ademir Xavier ^{[2
]}

机构：

[1] IFRJ CPAR, LISCOMP, Lab Instrumentacao & Simulacao Computac, BR-26600000 Paracambi, Brazil

[2] Univ Fed Rio de Janeiro, Escola Politecn, COPPE Dept Engn Nucl, Programa Engn Nucl, Caixa Postal 68509, BR-21941972 Rio De Janeiro, Brazil

来源：

RADIATION PHYSICS AND CHEMISTRY | 2020年 / 168卷 / 168期

关键词：

BNCT treatment; MCNP; Epithermal neutron; DOSIMETRY; ENERGY; BEAMS;

D O I：

10.1016/j.radphyschem.2019.108611

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This work presents a study of the influence of the field size of an epithermal neutron beam on the dose distribution in treatments with boron neutron capture therapy using an anthropomorphic voxel-based simulator. To calculate the doses in the tissues and organs of the head, the Monte Carlo N-Particle radiation transport code is used. The results suggest the possibility of using a beam of 6 cm in diameter for the treatment of tumours in the frontal lobe and parietal regions. With a beam of 10 cm in diameter, we could treat tumours located in the frontal lobe, parietal lobe and thalamus. The work also shows that the contribution of the secondary components (gamma rays, fast and thermal neutrons) in the calculation of the total dose can result in up to 15% of the dose in the tumour tissue, 68% of the dose in the healthy brain tissue and 87% of the dose in the non-cephalic regions.

引用

页数：6

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