Dose distribution in boron neutron capture therapy for the treatment of brain cancer

被引：2

作者：

Pereira, Leandro O. ^{[1
]}

Freitas, Renato P. ^{[1
]}

Ferreira, Douglas S. ^{[1
]}

Felix, Valter S. ^{[1
]}

Goncalves, Elicardo A. S. ^{[1
]}

Pimenta, Andre R. ^{[1
]}

Dutra, Rafael de Sousa ^{[1
]}

da Silva, Ademir Xavier ^{[2
]}

机构：

[1] IFRJ CPAR, LISCOMP, Lab Instrumentacao & Simulacao Computac, BR-26600000 Paracambi, Brazil

[2] Univ Fed Rio de Janeiro, Escola Politecn, COPPE Dept Engn Nucl, Programa Engn Nucl, Caixa Postal 68509, BR-21941972 Rio De Janeiro, Brazil

来源：

RADIATION PHYSICS AND CHEMISTRY | 2020年 / 168卷 / 168期

关键词：

BNCT treatment; MCNP; Epithermal neutron; DOSIMETRY; ENERGY; BEAMS;

D O I：

10.1016/j.radphyschem.2019.108611

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This work presents a study of the influence of the field size of an epithermal neutron beam on the dose distribution in treatments with boron neutron capture therapy using an anthropomorphic voxel-based simulator. To calculate the doses in the tissues and organs of the head, the Monte Carlo N-Particle radiation transport code is used. The results suggest the possibility of using a beam of 6 cm in diameter for the treatment of tumours in the frontal lobe and parietal regions. With a beam of 10 cm in diameter, we could treat tumours located in the frontal lobe, parietal lobe and thalamus. The work also shows that the contribution of the secondary components (gamma rays, fast and thermal neutrons) in the calculation of the total dose can result in up to 15% of the dose in the tumour tissue, 68% of the dose in the healthy brain tissue and 87% of the dose in the non-cephalic regions.

引用

页数：6

共 50 条

[1] Depth dose evaluation for prostate cancer treatment using boron neutron capture therapy
Davood Mirzaei
Hashem Miri-Hakimabad
Laleh Rafat-Motavalli
Journal of Radioanalytical and Nuclear Chemistry, 2014, 302 : 1095 - 1101
[2] Depth dose evaluation for prostate cancer treatment using boron neutron capture therapy
Mirzaei, Davood
Miri-Hakimabad, Hashem
Rafat-Motavalli, Laleh
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2014, 302 (03) : 1095 - 1101
[3] Reporting Dose in Boron Neutron Capture Therapy
Sauerwein, Wolfgang A. G.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2023, 38 (03) : 192 - 194
[4] Nanomaterials for boron and gadolinium neutron capture therapy for cancer treatment
Gao, Shanmin
Fu, Rongrong
Hosmane, Narayan S.
PURE AND APPLIED CHEMISTRY, 2015, 87 (02) : 123 - 134
[5] Carboranyl bisglycosides for the treatment of cancer by boron neutron capture therapy
Tietze, LF
Bothe, U
Griesbach, U
Nakaichi, M
Hasegawa, T
Nakamura, H
Yamamoto, Y
CHEMBIOCHEM, 2001, 2 (05) : 326 - 334
[6] Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment
Ailuno, Giorgia
Balboni, Alice
Caviglioli, Gabriele
Lai, Francesco
Barbieri, Federica
Dellacasagrande, Irene
Florio, Tullio
Baldassari, Sara
CELLS, 2022, 11 (24)
[7] Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer
Haapaniemi, Aaro
Kankaanranta, Leena
Saat, Riste
Koivunoro, Hanna
Saarilahti, Kauko
Makitie, Antti
Atula, Timo
Joensuu, Heikki
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 95 (01): : 404 - 410
[8] Boron Neutron Capture Therapy: a New View on the Cancer Treatment
Neves, Danielle Dias
Belian, Monica Freire
da Silva, Wagner Eduardo
Vilela, Eudice Correia
REVISTA VIRTUAL DE QUIMICA, 2021, 13 (01) : 270 - 282
[9] Calculation of whole-body organic dose in brain tumor treatment by boron neutron capture therapy
Matsumoto, T
Uchiyama, T
RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY, 2002, : 411 - 414
[10] Monte Carlo simulations to evaluate dose for possible treatment of brain cancers by boron neutron capture therapy
Jovanovic, Z.
Krstic, D.
Nikezic, D.
Matovic, M.
Krstic, R.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 : S379 - S379

← 1 2 3 4 5 →