Synthesis of 2,3,4-trisubstituted pyrrole derivatives via [3+2] cyclization of activated methylene isocyanides with 4-(arylidene)-2-substituted oxazol-5(4H)-ones

被引：8
|
作者：
Zhang, Jing [1 ,2 ]
Liu, Man [2 ]
Li, Chao [2 ]
Xu, Yan-Jun [1 ]
Dong, Lin [2 ]
机构：
[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 02期
关键词：
ALPHA-ACIDIC ISOCYANIDES; REGIOSELECTIVE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; POLYSUBSTITUTED PYRROLES; SUBSTITUTED PYRROLES; CONGOCIDINE; ISOCYANOACETATES; ANNULATION; ALKYNES; YLIDES;
D O I：
10.1039/c9qo01044k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient base-catalyzed [3 + 2] cyclization between isocyanides and 4-(arylidene)-2-substituted oxazol-5(4H)-ones has been successfully developed to form 2,3,4-trisubstituted and 2,2,3,4-tetrasubstituted pyrrole derivatives. This transition metal free reaction occurs at room temperature under environmentally friendly conditions, tolerating water and air.
引用
收藏
页码：420 / 424
页数：5
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