The smooth muscle cell antiproliferative activity of heparan sulfate model oligosaccharides

被引：4
|
作者：
Wessel, HP
Iberg, N
机构：
[1] Pharma Division, Preclinical Research, F.HOFFMANN-LA ROCHE LTD.
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期
关键词：
D O I：
10.1016/0960-894X(96)00047-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Heparan sulfate model oligosaccharides were devised with the simplyfying assumptions that i) carboxyl-reduction and subsequent sulfation of heparan sulfate does not decrease the SMC antiproliferative activity, and ii) N-Sulfates in glucosamines can be replaced by O-sulfates. These heparan sulfate model oligosaccharides are more active than analogous heparin fractions.
引用
收藏
页码：427 / 430
页数：4
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