A stable DNA duplex containing a non-hydrogen-bonding and non-shape-complementary base couple:: Interstrand stacking as the stability determining factor

被引：0
|
作者：
Brotschi, C [1 ]
Häberli, A [1 ]
Leumann, CJ [1 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 16期
关键词：
DNA recognition; DNA structures; N ligands; nucleobases; oligonucleotides;
D O I：
10.1002/1521-3773(20010817)40:16<3012::AID-ANIE3012>3.0.CO;2-Y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The stabilizing effect of a dG:dC base-pair can also be imparted to a DNA duplex by a non-hydrogen- bonding, non-shape-complementary nucleoside analogue when interstrand stacking interactions come into play. This is the case, for example, with dBP, which has a bipyridyl (BP) residue as a nucleobase surrogate (the picture shows a dBP:dBP pair).
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页码：3012 / 3014
页数：3
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