"One-Pot" Multicomponent Approach to Indolizines and Pyrido[1,2-a]indoles

被引：77
|
作者：
Zhu, Huajian [1 ]
Stoeckigt, Joachim [1 ]
Yu, Yongping [1 ]
Zou, Hongbin [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Mat Med, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 10期
基金：
中国国家自然科学基金;
关键词：
N-FUSED HETEROCYCLES; CATALYZED CYCLOISOMERIZATION; RECEPTOR ANTAGONISTS; DERIVATIVES; INHIBITOR; FLUORESCENT; DISCOVERY; PYRIDINES;
D O I：
10.1021/ol200883w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthetic protocol for efficient and regiospecifc assembly of indolizines and pyrido[1,2-a]indoles by coupling of substituted methyl bromides and alkynes with corresponding pyrrole-2-carboxaldehyde and 1H-indole-2-carboxaldehyde has been developed. Additionally, a possible mechanism for the reaction is proposed.
引用
收藏
页码：2792 / 2794
页数：3
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