Total synthesis and biological evaluation of nannocystin analogues modified at the polyketide phenyl moiety

被引：13

作者：

Tian, Yunfeng

Ding, Yahui

Xu, Xiaolong

Bai, Yanju

Tang, Yang

Hao, Xin

Zhang, Weicheng ^{[1
]}

Chen, Yue ^{[1
]}

机构：

[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 33期

基金：

中国国家自然科学基金;

关键词：

Nannocystin; Structure-activity relationship; Anticancer; Eukaryotic elongation factor 1A; CHONDRAMIDE-C; F-ACTIN; DIDEMNIN; AX;

D O I：

10.1016/j.tetlet.2018.07.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of a focused set of 10 nannocystin analogues 3a-3j modified at the polyketide phenyl moiety was reported. These compounds were evaluated against three cancer cell lines. Compared with the naturally occurring congener 3a, the other synthetic variants either preserved or lose antiproliferative activity at varying degrees. Moreover, the potent analogues also displayed comparable levels of cytotoxicity toward two normal cell lines. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：3206 / 3209

页数：4

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