Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels

被引：20

作者：

Katzer, W ^{[1
]}

Blackburn, M ^{[1
]}

Charman, K ^{[1
]}

Martin, S ^{[1
]}

Penn, J ^{[1
]}

Wrigley, S ^{[1
]}

机构：

[1] TerraGen Discovery UK Ltd, Slough, Berks, England

来源：

BIOCHEMICAL ENGINEERING JOURNAL | 2001年 / 7卷 / 02期

关键词：

filamentous organism; fungi; antinomycetes; tubes; shake-flask; secondary metabolite; fermentation;

D O I：

10.1016/S1369-703X(00)00112-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The choice of small-scale fermentation systems contributes significantly to a successful scale-up. Creasing of flasks and the chosen shaker parameters influence the production of secondary metabolites in a strain- and even compound-specific manner. Using actinomycetes and fungi as model organisms the influence of the small-scale fermentation system on the production of various secondary metabolites is described and the effects on screening success and scale-up are considered. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：127 / 134

页数：8

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