Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels

被引：20

作者：

Katzer, W ^{[1
]}

Blackburn, M ^{[1
]}

Charman, K ^{[1
]}

Martin, S ^{[1
]}

Penn, J ^{[1
]}

Wrigley, S ^{[1
]}

机构：

[1] TerraGen Discovery UK Ltd, Slough, Berks, England

来源：

BIOCHEMICAL ENGINEERING JOURNAL | 2001年 / 7卷 / 02期

关键词：

filamentous organism; fungi; antinomycetes; tubes; shake-flask; secondary metabolite; fermentation;

D O I：

10.1016/S1369-703X(00)00112-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The choice of small-scale fermentation systems contributes significantly to a successful scale-up. Creasing of flasks and the chosen shaker parameters influence the production of secondary metabolites in a strain- and even compound-specific manner. Using actinomycetes and fungi as model organisms the influence of the small-scale fermentation system on the production of various secondary metabolites is described and the effects on screening success and scale-up are considered. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：127 / 134

页数：8

共 50 条

[1] Effective data treatment for decreasing the difference from shake flasks to fermentors scale-up
Fan, Daidi
Yu, Juntang
Huadong Ligong Daxue Xuebao /Journal of East China University of Science and Technology, 1995, 21 (06): : 680 - 683
[2] CAROTENOID PRODUCTION BY SPORIDIOBOLUS PARAROSEUS IN AGROINDUSTRIAL MEDIUM: OPTIMIZATION OF CULTURE CONDITIONS IN SHAKE FLASKS AND SCALE-UP IN A STIRRED TANK FERMENTER
Borba, Carina Molins
Tavares, Millene das Neves
Moraes, Caroline Costa
de Medeiros Burkert, Janaina Fernandes
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING, 2018, 35 (02) : 509 - 520
[3] Scale-Up of Pigment Production by the Marine-Derived Filamentous Fungus, Talaromyces albobiverticillius 30548, from Shake Flask to Stirred Bioreactor
Venkatachalam, Mekala
Mares, Gary
Dufosse, Laurent
Fouillaud, Mireille
FERMENTATION-BASEL, 2023, 9 (01):
[4] Numerical scale-up study for orthokinetic agglomeration in stirred vessels
Hollander, ED
Derksen, JJ
Portela, LM
Van den Akker, HEA
AICHE JOURNAL, 2001, 47 (11) : 2425 - 2440
[5] SCALE-UP OF THE NECESSARY POWER INPUT IN STIRRED VESSELS WITH SUSPENSIONS
GEISLER, RK
BUURMAN, C
MERSMANN, AB
CHEMICAL ENGINEERING JOURNAL AND THE BIOCHEMICAL ENGINEERING JOURNAL, 1993, 51 (01): : 29 - 39
[6] High throughput in biotechnology: From shake-flasks to fully instrumented microfermentors
Marques, Marco P.C.
Cabral, Joaquim M.S.
Fernandes, Pedro
Recent Patents on Biotechnology, 2009, 3 (02) : 124 - 140
[7] Quantitative measurements of mixing intensity in shake-flasks and stirred tank reactors - Use of the Mixmeter, a mixing process analyzer
Gerson, DF
Kole, MM
BIOCHEMICAL ENGINEERING JOURNAL, 2001, 7 (02) : 153 - 156
[8] From shake flasks to stirred fermentors:: Scale-up of an extractive fermentation process for 6-pentyl-α-pyrone production by Trichoderma harzianum using volumetric power input
Rocha-Valadez, J. Antonio
Estrada, Marlene
Galindo, Enrique
Serrano-Carreon, Leobardo
PROCESS BIOCHEMISTRY, 2006, 41 (06) : 1347 - 1352
[9] Laboratory scale cultivation of Salinispora tropica in shake flasks and mechanically stirred bioreactors
Zuzana Jezkova
Elisa Binda
Tomas Potocar
Flavia Marinelli
Martin Halecky
Tomas Branyik
Biotechnology Letters, 2021, 43 : 1715 - 1722
[10] Enhanced Natamycin production by Streptomyces natalensis in shake-flasks and stirred tank bioreactor under batch and fed-batch conditions
Elsayed, Elsayed Ahmed
Farid, Mohamed A.
El-Enshasy, Hesham A.
BMC BIOTECHNOLOGY, 2019, 19 (1)

← 1 2 3 4 5 →