Selective Intramolecular C-H Amination through the Metalloradical Activation of Azides: Synthesis of 1,3-Diamines under Neutral and Nonoxidative Conditions

被引：168

作者：

Lu, Hongjian ^{[1
]}

Jiang, Huiling ^{[1
]}

Wojtas, Lukasz ^{[1
]}

Zhang, X. Peter ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 52期

基金：

美国国家科学基金会;

关键词：

C-H amination; cobalt porphyrins; 1,3-diamines; nitrene transfer; sulfamoyl azides; TRANSITION-METAL-COMPLEXES; ORGANIC AZIDES; EFFICIENT; INSERTION; BONDS; FUNCTIONALIZATION; AZIRIDINATION; AMIDATION; DESIGN; AMINES;

D O I：

10.1002/anie.201005552

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N2 is the only by-product in a stereospecific and highly diastereoselective intramolecular C-H amination of sulfamoyl azides with a cobalt(II)-based metalloradical catalyst (see scheme). The catalytic system has an unusual capacity for the efficient amination of strong primary C-H bonds, as well as secondary and tertiary C-H bonds, and functional-group tolerance is excellent owing to the neutral and nonoxidative conditions. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10192 / 10196

页数：5

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