The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections

被引：38

作者：

Cappiello, Floriana ^{[1
]}

Loffredo, Maria Rosa ^{[1
]}

Del Plato, Cristina ^{[2
,3
]}

Cammarone, Silvia ^{[2
]}

Casciaro, Bruno ^{[3
]}

Quaglio, Deborah ^{[2
]}

Mangoni, Maria Luisa ^{[1
]}

Botta, Bruno ^{[2
]}

Ghirga, Francesca ^{[3
]}

机构：

[1] Sapienza Univ Rome, Dept Biochem Sci, Pasteur Italia Fdn Cenci Bolognetti, Ple Aldo Moro 5, I-00185 Rome, Italy

[2] Sapienza Univ Rome, Dept Chem & Technol Drugs, Dept Excellence 2018 2022, Ple Aldo Moro 5, I-00185 Rome, Italy

[3] Ist Italiano Tecnol, Ctr Life Nano Sci Sapienza, Viale Regina Elena 291, I-00161 Rome, Italy

来源：

ANTIBIOTICS-BASEL | 2020年 / 9卷 / 06期

关键词：

antibiotic resistance; plant secondary metabolites; plant-derived natural products; terpenes; diterpenes; triterpenes; multidrug-resistant strains; GRAM-NEGATIVE BACTERIA; METHICILLIN-RESISTANT; MULTIDRUG-RESISTANT; STAPHYLOCOCCUS-AUREUS; NATURAL-PRODUCTS; ANTIMICROBIAL RESISTANCE; POLYALTHIA-LONGIFOLIA; LABDANE DITERPENOIDS; CLERODANE DITERPENE; DRUG DISCOVERY;

D O I：

10.3390/antibiotics9060325

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field of drug-discovery has revaluated the potential of natural products as a unique source for new biologically active molecules and scaffolds for the medicinal chemistry. In this review, we first contextualized the worldwide problem of antibiotic resistance and the importance that natural products of plant origin acquire as a source of new lead compounds. We then focused on terpenes and their potential development as antimicrobials, highlighting those studies that showed an activity against conventional antibiotic-resistant strains.

引用

页码：1 / 33

页数：34

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