Immunosuppression following dietary aflatoxin B1 exposure: a review of the existing evidence

被引：40

作者：

Mohsenzadeh, Mahdieh Sadat ^{[1
]}

Hedayati, Narges ^{[1
]}

Riahi-Zanjani, Bamdad ^{[2
]}

Karimi, Gholamreza ^{[3
]}

机构：

[1] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran

[2] Mashhad Univ Med Sci, Sch Med, Med Toxicol Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran

来源：

TOXIN REVIEWS | 2016年 / 35卷 / 3-4期

关键词：

Aflatoxin B1; Aspergillus; contaminated food; immunological outcomes; molds; MURINE PERITONEAL-MACROPHAGES; NATURAL-KILLER-CELLS; GUINEA-PIGS; IN-VITRO; SPLENIC LYMPHOCYTES; COMPLEMENT ACTIVITY; IMMUNE-RESPONSE; HUMAN MONOCYTES; MESSENGER-RNA; T-CELLS;

D O I：

10.1080/15569543.2016.1209523

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Aflatoxin B1 is a toxic and secondary metabolite secreted by some natural molds, such as Aspergillus, and has been associated with severe toxic effects in humans and animals. They contaminate food and feed supplies, and are commonly found in grains and nuts. These toxins are synthesized under suitable physical, chemical and biological conditions. High-temperature stress, moisture stress and insect injury of the product are the most important factors in mold invasion and subsequent toxin production. These toxins have different carcinogenic and cytotoxic properties. The immunological effects of exposure to AFB1 are assessed in the present review.

引用

页码：121 / 127

页数：7

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