General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald-Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles

被引：8

作者：

Gribanov, Pavel S. ^{[1
]}

Philippova, Anna N. ^{[1
]}

Topchiy, Maxim A. ^{[2
]}

Minaeva, Lidiya, I ^{[2
]}

Asachenko, Andrey F. ^{[2
]}

Osipov, Sergey N. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Vavilova Str, Moscow 119991, Russia

[2] Russian Acad Sci, AV Topchiev Inst Petrochem Synth, Leninskiy Prospect 29, Moscow 119991, Russia

来源：

MOLECULES | 2022年 / 27卷 / 06期

基金：

俄罗斯科学基金会;

关键词：

cross-coupling; amination; triazoles; palladium; carbene ligands; heterocycles; AZIDE-ALKYNE CYCLOADDITION; CATALYZED AMINATION; CLICK CHEMISTRY; 1,2,3-TRIAZOLE; ARYL; DERIVATIVES; COMPLEXES; SUZUKI; RING; CONSTRUCTION;

D O I：

10.3390/molecules27061999

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient access to the novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed. The method is based on Buchwald-Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-Dipp)Pd(cinn)Cl] bearing expanded-ring N-heterocyclic carbene ligand is the most active catalyst for the process to afford the target molecules in high yields.

引用

页数：16

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